Osteosarcoma is the most common type of bone cancer. Although stage I osteosarcoma has a promising prognosis, stage III osteosarcoma with lung metastases with only about 30% survival rate is worrying. Expression of EGFR and its downstream proteins has been regularly observed in osteosarcoma. In this book, the main focus is on two major aims: 1.Analysis of the role of EGFR signaling during bone tumor formation by breeding H2-c-fosLTR transgenic mice, that develop OS with 100% penetrance, to mice that harbor either reduced (Egfrwa2/wa2) or elevated (Col1-AREG) EGFR signaling; 2.Analysis of the effect of EGFR inhibition on proliferation, viability and apoptosis as well as on EGFR downstream signaling proteins in c fos transgenic osteosarcoma cells.

Parastoo Shahrouzi is a Phd student at CICBioGune in Bilbao,Spain. She finished her Bachelor study in Iran and continued her education at the university of Vienna.She later moved to Spain in 2017 to pursue her career as a Phd student with a major focus on Cancer research. Part of her master thesis project was published in the EMBO journal in 2018.