An important mechanism to achieve regulatory specificity in diverse biological processes is through the combinatorial interplay between different regulators, such as amongst transcription factors during transcriptional regulation or between RNA binding proteins and microRNAs during transcript degradation control. To advance our understanding of combinatorial regulation, this book systematically describes the computational methodology for predicting genome-wide co-binding between biological regulators.

Peng Jiang received his PhD from the department of computer science at Princeton University. His major work is in developing methods to find patterns and functional output of combinatorial interplay between biological regulators, such as between Transcription factors or between RNA binding proteins and microRNAs.