InhaltsangabeLINKAGE DISEQUILIBRIUM AND ASSOCIATION MAPPING: ANALYSIS AND APPLICATIONS. Chapter 1. Linkage disequilibrium and association mapping - an introduction. (Andrew Collins). Chapter 2. A history of association mapping (Newton E Morton). Chapter 3. Linkage disequilibrium maps and location databases.(William Tapper). Chapter 4. LDMAP: The construction of high-resolution linkage disequilibrium maps of the human genome. (Kuo T-Y, Lau W, Collins A). Chapter 5. Linkage disequilibrium as a tool for detecting the signatures of selection. (Sarah Ennis). Chapter 6. The genetic basis of complex traits - rare variants or 'common gene common disease'? (Sudha K Iyengar, Robert C Elston ). Chapter 7. Linkage Disequilibrium Mapping for Complex Disease Genes (Andrew DeWan, Robert J. Klein, Josephine Hoh). Chapter 8. Linkage disequilibrium maps and disease association mapping (Nik Maniatis). Chapter 9. Coalescent methods for fine-scale disease gene mapping (Andrew P. Morris). Chapter 10. Family Based Linkage Disequilibrium Tests Using general pedigrees (Yin Yao Shugart, Lina Chen, Terri Beaty). Chapter 11. Association studies using familial cases: an efficient strategy for identifying low penetrance disease alleles (Emily L. Webb, Richard S. Houlston). Chapter 12. Association mapping using pooled DNA (Hsin-Chou Yang and Cathy S. J. Fann). Chapter 13. Selecting SNPs for Association Studies with SNPbrowser Software (Francisco M. De La Vega) Chapter 14. Avoiding false discoveries in association studies (Chiara Sabatti). Chapter 15. Gene mapping in asthma related traits. (Tarja Laitinen). Chapter 16. Identifying susceptibility variants for type 2 diabetes. (Eleftheria Zeggini and Mark I McCarthy).